Fig. 3.
Antinociceptive effects of CEF after 7-day pretreatment (A) and after an acute treatment (B). Each column represents the mean ± SEM number of writhes induced by acetic acid (i.p.). **P < 0.01 compared with control group (Tukey honestly significant difference post hoc test after one-way ANOVA). (C) Log dose–response curves for CEF antinociception after 7-day pretreatment and after an acute treatment. ##P < 0.01 compared with the effect of the same dose after an acute treatment (Tukey honestly significant difference post hoc test after two-way ANOVA). %AN = percentage of antinociceptive activity; CEF = ceftriaxone; i.p. = intraperitoneal.