American Society of Anesthesiologists

Fig. 9.

Isobolograms for CEF + IBU (A), CEF + CEL (B), CEF + PAR (C), and CEF + LEV (D) combinations in the visceral nociception model in mice. The ED50 values for each drug are plotted at the axes. The straight line connecting the each ED50 value is the theoretical additive line, and the point in this line is the ED50 add. There is a significant difference (P < 0.05; t test) between the ED50 add and the ED50 mix in each isobologram indicating a synergistic drug interaction for all of the examined combinations. CEL = celecoxib; CEF = ceftriaxone; ED50 = effective dose that produces 50% of the antinociceptive effect; ED50 add = theoretical additive ED50; ED50 mix = experimental ED50 for drug mixture; IBU = ibuprofen; LEV = levetiracetam; PAR = paracetamol.

Isobolograms for CEF + IBU (A), CEF + CEL (B), CEF + PAR (C), and CEF + LEV (D) combinations in the visceral nociception model in mice. The ED₅₀ values for each drug are plotted at the axes. The straight line connecting the each ED₅₀ value is the theoretical additive line, and the point in this line is the ED_{50 add}. There is a significant difference (P < 0.05; t test) between the ED_{50 add} and the ED_{50 mix} in each isobologram indicating a synergistic drug interaction for all of the examined combinations. CEL = celecoxib; CEF = ceftriaxone; ED₅₀ = effective dose that produces 50% of the antinociceptive effect; ED_{50 add} = theoretical additive ED₅₀; ED_{50 mix} = experimental ED₅₀ for drug mixture; IBU = ibuprofen; LEV = levetiracetam; PAR = paracetamol.

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