Fig. 2.
Standard curves for dabigatran anticoagulation using the diluted thrombin time (TT) assay in the presence and absence of Beriplex (A), NovoSeven (B), Factor Eight Inhibitor Bypassing Activity (FEIBA) (C), and Bebulin (D). All coagulation factor concentrates (CFCs) were tested with a final concentration of 1 IU/ml, except NovoSeven (100 nM, equivalent to plasma levels of CFC achieved with approximately 500 μg/kg). Data shown as mean ± SD, n = 3 volunteers. Bebulin (Baxter BioScience, Westlake Village, CA); Beriplex (CSL Behring, Marburg, Germany); FEIBA (Baxter AG, Vienna, Austria); NovoSeven (NovoNordisk, Bagsværd, Denmark).