Box-whisker plots illustrating the time course of changes in mean Global Efficiency calculated in 5 min time bins for (A) full brain, (B) frontal, and (C) parietal networks either normal controls (NC) (left column) or children with emergence delirium (right column). Similar temporal trends with respect to clinical grouping and brain network were also observed using the common average derivation (results not shown). Stars indicate bins that were significantly different between emergence delirium and NC groups. Boxes represent interquartile ranges, lines enclosed within boxes (and connected lines) median values, whiskers represent the largest (smallest) nonoutlier, and crosses represent outliers (defined as values extending further than 1.5 times the interquartile range—equivalent to approximately 3 SD for normally distributed data).