Easily releasable myofilaments (CON: n = 7; MV: n = 8; MV + epoxomicin: n = 7). Values are mean percentage change ± SD. *Significantly different versus CON (P < 0.0167). Exact P values for all comparisons are listed below the graph. Acutely anesthetized control animals (CON); 12 h mechanically ventilated animals, no treatment (MV); 12 h of MV, treatment with the proteasome inhibitor epoxomicin (MV + epoxomicin).