Fig. 7.
Genetic deletion of Hsp72 attenuates the increased mortality associated with a prior heat-shock response in a mouse model of Pseudomonas aeruginosa pneumonia. C57BL/6 wild-type (WT) or Hsp72-null mice were left untreated or underwent a heat-shock response with whole-body hyperthermia that was followed 24 h later by airspace instillation of P. aeruginosa (PAK strain, 1 × 107 colony-forming units [CFU]) or its vehicle. Kaplan–Meier survival analysis was performed (n = 10 mice per group). WT but not Hsp72-null mice that underwent a heat-shock response and had their airspaces instilled with P. aeruginosa PAK died significantly earlier (*P = 0.05) than the WT mice that did not undergo a heat-shock response before the onset of P. aeruginosa pneumonia.