Fig. 2.
The behavioral tests postisoflurane exposure. The mice had normal ambulatory distance traveled and time spent in the center in the open-field test (A and B) in the five groups 24-h postisoflurane exposure. Neuregulin 1 (NRG1)-β1 increased the freezing time to context 48-h postisoflurane exposure in the isoflurane plus NRG1-β1 group compared with that in the isoflurane group, which was abolished by AG1478 in the isoflurane plus NRG1-β1 plus AG1478 group (C). No significant difference was detected in the freezing time to tone among the groups (D) 48-h postisoflurane exposure. Data are mean ± SD (n = 10 mice for each group; ***P < 0.005 vs. the control group; #P < 0.05 vs. the isoflurane group; +P < 0.05 vs. the isoflurane plus NRG1-β1 group).