Fig. 3.
The hippocampal levels of neuregulin 1 (NRG1), p-ErbB4, and ErbB4 48-h postisoflurane exposure. The isoflurane exposure reduced the hippocampal concentrations of NRG1 in the isoflurane group (A) (n = 4 mice for each group). The isoflurane exposure reduced the hippocampal p-ErbB4/ErbB4 significantly in the isoflurane group (B and C) (n = 4 mice for each group). NRG1-β1 reversed the decrease in the hippocampal p-ErbB4/ErbB4 induced by the isoflurane exposure in the isoflurane plus NRG1-β1 group (B and C), which was abolished by AG1478 in the isoflurane plus NRG1-β1 plus AG1478 group (B and C) (n = 4 mice for each group). Data are mean ± SD. (*P < 0.05, **P < 0.01 vs. the control group; ##P < 0.01 vs. the isoflurane group; +P < 0.05 vs. the isoflurane plus NRG1-β1 group.)

The hippocampal levels of neuregulin 1 (NRG1), p-ErbB4, and ErbB4 48-h postisoflurane exposure. The isoflurane exposure reduced the hippocampal concentrations of NRG1 in the isoflurane group (A) (n = 4 mice for each group). The isoflurane exposure reduced the hippocampal p-ErbB4/ErbB4 significantly in the isoflurane group (B and C) (n = 4 mice for each group). NRG1-β1 reversed the decrease in the hippocampal p-ErbB4/ErbB4 induced by the isoflurane exposure in the isoflurane plus NRG1-β1 group (B and C), which was abolished by AG1478 in the isoflurane plus NRG1-β1 plus AG1478 group (B and C) (n = 4 mice for each group). Data are mean ± SD. (*P < 0.05, **P < 0.01 vs. the control group; ##P < 0.01 vs. the isoflurane group; +P < 0.05 vs. the isoflurane plus NRG1-β1 group.)

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