Increased incidence of spontaneous activity (SA) in dorsal root ganglion neurons from animals with paclitaxel neuropathy. (A) Paclitaxel chemotherapy induced a significant increase of SA from dorsal root ganglion myelinated neurons including large- (P = 0.003) and medium-sized (P = 0.027) neurons. *P < 0.05, **P < 0.01, chi-square test. (B) An example of irregular SA recorded from a medium-sized neuron, noticing the subthreshold membrane potential oscillations between each discharge. (C) Continuous discharges were recorded from a spontaneously active large neuron. (D) Spontaneous bursting discharges were recorded from a large neuron after paclitaxel chemotherapy. Subthreshold oscillations (arrows) were obvious between each episode of bursting discharges.