(A) Peak responses of total lung resistance (RL) in vivo to acetylcholine in the four groups of sensitized guinea pigs (n = 8 each). S = sevoflurane; R1.0 = rolipram1.0; S+R1.0 = sevoflurane/rolipram1.0. *P < 0.05 versus the sensitized group; #P < 0.05 versus the S group, at the same concentrations of acetylcholine. (B) Peak responses of total lung resistance (RL) in vivo to acetylcholine in the four groups of sensitized guinea pigs (n = 8 each). S = sevoflurane; F1.0 = roflumilast1.0; S+F1.0 = sevoflurane/roflumilast1.0. *P < 0.05 versus the sensitized group; #P < 0.05 versus the S group, at the same concentrations of acetylcholine. (C) Peak responses of total lung resistance (RL) in vivo to acetylcholine in the four groups of sensitized guinea pigs (n = 8 each). R1.0 = rolipram1.0; F1.0 = roflumilast1.0; S+R1.0 = sevoflurane/rolipram1.0; S+F1.0 = sevoflurane/roflumilast1.0. ^P < 0.05 versus the R1.0 group, at the same concentrations of acetylcholine.
