Fig. 5.
Reduction of Na+/Ca2+ exchange current (INCX) by desflurane. (A) Time course of changes in membrane currents measured at +40 and −120 mV in the voltage-ramp protocol, during the application of 12% desflurane (DES) and 5 mM NiCl2, as indicated. (B) Current–voltage relationships of membrane currents recorded at time points indicated by letters (a to e) in A. (C) Difference currents obtained by digital subtraction of the current traces shown in B, as indicated (a–b, desflurane-sensitive current; a–d, NiCl2-sensitive current). (D) Percent inhibition of the forward and reverse mode INCX by 6% (n = 6, N = 3) and 12% desflurane (n = 8, N = 3), measured at similar driving force of 60 mV. The fractional block induced by desflurane was expressed as the percent of the total INCX. *P < 0.05 compared with the control. NS = not significant.

Reduction of Na+/Ca2+ exchange current (INCX) by desflurane. (A) Time course of changes in membrane currents measured at +40 and −120 mV in the voltage-ramp protocol, during the application of 12% desflurane (DES) and 5 mM NiCl2, as indicated. (B) Current–voltage relationships of membrane currents recorded at time points indicated by letters (a to e) in A. (C) Difference currents obtained by digital subtraction of the current traces shown in B, as indicated (a–b, desflurane-sensitive current; a–d, NiCl2-sensitive current). (D) Percent inhibition of the forward and reverse mode INCX by 6% (n = 6, N = 3) and 12% desflurane (n = 8, N = 3), measured at similar driving force of 60 mV. The fractional block induced by desflurane was expressed as the percent of the total INCX. *P < 0.05 compared with the control. NS = not significant.

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