Kaplan–Meier survival analysis stratified by β-adrenoreceptor (βAR) blocker therapy. (A) Patients on βAR blockade (n = 1,267) and patients without β-adrenergic receptor blockade (n = 360). (B) Analyses for haplotype *3 positive patients with (n = 739) and without β-adrenergic receptor (n = 196) and of haplotype negative patients with (n = 528) and without β-adrenergic receptor blockade (n = 164). P values represent log-rank test for comparison of all curves.