Fig. 5.
Effects of ALX5407 and ALX1393 on motor coordination: Motor coordination was assessed by the Rat Rotarod (Ugo Basile, Comerio, Italy) (fall-off-time in seconds over time) during application of either vehicle or the highest dose of the glycine transporter 1 inhibitor ALX5407 (Sigma-Aldrich®, St. Louis, MO) (200 μg/kg per day) or glycine transporter 2 inhibitor ALX1393 (Sigma-Aldrich®) (200 μg/kg per day). Data are presented as mean ± SEM (n = 6).