Fig. 3.
Effect of valproic acid (VPA) and zinc protoporphyrin IX (ZnPP) on pulmonary artery pressure (ΔPAP). PAP increased significantly in the ischemia–reperfusion (I/R) group. The increase in PAP was attenuated significantly by treatment with VPA, but not when ZnPP was added. Data are expressed as mean ± SD (n = 6 per group). ***P < 0.001 compared with the control group; +P < 0.05, ++P < 0.01, +++P < 0.001 compared with the I/R–vehicle group; #P < 0.05, ##P < 0.01, ###P < 0.001 compared with the I/R + VPA 300 group.