Thrombin generation (extrinsic activation) after addition of 0−1.25 IU/ml 4F-PCC to edoxaban-containing rabbit plasma in vitro. (A) Peak thrombin generation; (B) endogenous thrombin potential (ETP). No edoxaban was added to control plasma. 4F-PCC = four-factor prothrombin complex concentrate; IU = international unit.