Fig. 1.
![Schematic flowchart of study design (top) and timeline of the procedure (bottom). Dashed lines represent additional groups in which tidal volume (VT) = 6 ml/kg was applied and positive end-expiratory pressure (PEEP) adjusted to similar respiratory system plateau pressure (Pplat,rs) achieved when ΔP,LMEAN and ΔP,LHIGH were associated with high VT (13 ml/kg [Pplat,rs = 14 cm H2O] and 22 ml/kg [Pplat,rs = 17 cm H2O]). ARDS = acute respiratory distress syndrome; Fio2 = inspiratory fraction of oxygen; I:E = inspiratory-to-expiratory ratio; i.t. = intratracheally; LPS = Escherichia coli lipopolysaccharide; NV = nonventilated group; RR = respiratory rate; ΔP,L = transpulmonary driving pressure.](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/123/2/10.1097_aln.0000000000000716/2/28ff01.png?Expires=1716905813&Signature=aTX76IxoOm0Hrfn08YoL-jH1BFaQyWN2qri4I9-7p7jYC-qYtEP6q4JmCEQZl1vzVs5Usb0lYOkIKAYYyUDLRANbT4GkM7j3BhH54woVALspaof2bSl2gaHrzOpHGwYBGqzvE-VWW1QZ~MSAfTdOnmV88VtUkTpJXR~55b1SCai2PeHrI-vcFbhhCfjR2vCQCoIc~js0OjIuvHOsiRXKiqSJ~BmgVW3h-D7ZeJ5hB-XTRWuWUw1Kh1HLgk0E9XqKeYTNB-3SnaEAWx9ML5VJ6CpkLg8TOSjcmKSoSicDPbdyyNGxLwqDpREecSssXRsjkizlnLGf5pB5AI2RmiguNg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Schematic flowchart of study design (top) and timeline of the procedure (bottom). Dashed lines represent additional groups in which tidal volume (VT) = 6 ml/kg was applied and positive end-expiratory pressure (PEEP) adjusted to similar respiratory system plateau pressure (Pplat,rs) achieved when ΔP,LMEAN and ΔP,LHIGH were associated with high VT (13 ml/kg [Pplat,rs = 14 cm H2O] and 22 ml/kg [Pplat,rs = 17 cm H2O]). ARDS = acute respiratory distress syndrome; Fio2 = inspiratory fraction of oxygen; I:E = inspiratory-to-expiratory ratio; i.t. = intratracheally; LPS = Escherichia coli lipopolysaccharide; NV = nonventilated group; RR = respiratory rate; ΔP,L = transpulmonary driving pressure.
