Effects of dabigatran on parameters of thrombin generation in the modified CAT® assay. At a therapeutic level (0.4 µM), the major effect of dabigatran was on the lag (A) and area under the curve (AUC) (B), whereas at supratherapeutic levels (1 or 2 µM), dabigatran affected the rate of thrombin generation (C) and peak level (D), as well. The graphs show the mean ± SD of data from six experiments with different blood donors. Results are expressed as a percent of the control value in the absence of dabigatran in the same experiment. *P < 0.05 compared to control in a one-way repeated-measures ANOVA with Tukey method for multiple comparisons. The CAT^® assay is a product of Diagnostica Stago (Parsippany, NJ).