Fig. 5.
Effect of route of administration on hMSC efficacy. Delivery of hMSCs by the intravenous and intratracheal routes restored arterial oxygenation (A), increased static lung compliance (B), had no effect on lung wet:dry weight ratios (C), decreased BAL protein concentrations (D), reduced BAL total cell counts (E), and decreased the proportion of BAL neutrophils (F) 24 h after ventilator-induced lung injury. The intraperitoneal administration route was less effective. Error bars represent standard deviation. n = 10 animals per hMSC group and n = 5 animals per Vehicle group. BAL = bronchoalveolar lavage; hMSC = human mesenchymal stromal cell; IP = intraperitoneal; IT = intratracheal; IV = intravenous; Vehicle = treatment with vehicle alone. *Significantly (P < 0.05) different from Vehicle group for each administration route.