Current characteristics of WT and mutant channels. (A) Recordings of both WT and p.L1612P mutant channels, normalized to the same peak current. (B) Slower current decay of the p.L1612P channel. (C) No difference in persistent current is observed between the WT and p.L1612P channel at 50 and 100 ms and its value reaches below 1% at 100 ms after the peak. LP = p.L1612P; WT = wild type (**P < 0.01 and ***P < 0.001).