Relationship between the half-maximal direct activating concentration of etomidate and etomidate analogs (EC₅₀) and their octanol:water partition coefficients. The dashed line is a linear fit of the logarithm-transformed data. The slope of the fitted line was 0.13 ± 0.20 µM, and the coefficient of determination (r²) was 0.019. The name and structure of each numbered compound is given in table 1.