Systematic administration of CX546 relieves depression-like behaviors in paw incision (PI)–treated rats. (A) Intraperitoneal administration of CX546 (10 mg/kg) relieved depression-like behaviors in PI-treated rats, as shown by a decrease of immobility during the force swim test, compared with control group. Unpaired two-tailed Student’s t test: dimethyl sulfoxide (DMSO) group, n = 3; CX546 group, n = 3; *P = 0.0486. (B) Systemic administration of CX546 (10 mg/kg) did not change locomotion in PI-treated rats, compared with DMSO injection. Two-way ANOVA with repeated measures: DMSO group, n = 7; CX546 group, n = 7; P = 0.8364.